Liver bile contains bile acid which is very important for digestion and absorption of cholesterol, fat and fat soluble vitamin into small intestine. Liver bile is normally stored into gall bladder. Many waste products like bilirubin are normally eliminated from the body by secretion into bile. In adult human daily produce 500 to 800 ml of bile and similar amount into other animal. Usually the secretion of liver bile can be considered to occur into two stages:
- At initial stage, hepatocytes normally secrete bile into canaliculi, from which it usually flows into bile ducts. This liver bile contains large quantities of cholesterol, bile acids and other organic molecules.
- As liver bile flows through the bile ducts it is usually modified by addition of a watery and bicarbonate-rich secretion from ducal epithelial cells.
Major Function of liver bile
Live bile is so much necessary for the digestion. Liver bile is enabling to digestion of vitamin and the fat together with the pancreatic juice. The absorption of protein nutrient calcium lipo-soluble vitamin is depending upon the mixing of food with the bile.
When the fat in not absorbed and they are normally remain into the intestine. In this situation calcium will not be absorbed.
Approximately eighty percent of the liver bile is normally recycled and turn into the liver. The liver bile is also used for the eliminate refuse deriving from the damage of red blood cell.
Normally over quart of liver bile should exit from the body every day. Since the liver bile is loaded with cholesterol, this daily excretion of liver bile is a key method for keeping cholesterol level low. But if the liver bile duct are choked with the debits, then only half as much liver bile is produce and excreted expect cholesterol level are rise and the digestion to be bad.
There are normally thousand of bits of trash are accumulated into the liver bile duct. Sometime thay are turn into the stone, these are called gall stone.
Anatomy of liver bile
The biliary system are consist of some organ like gallbladder, bile duct and associated structure that are normally involved in transportation and production of liver bile. The transportation of live bile is occurred in following ways:
- When the liver cells secrete liver bile that is collected by a system of ducts that flow from the liver through the left and right hepatic ducts.
- These ducts finally drain into the common hepatic duct.
- The common hepatic duct then joins into the cystic duct from the gallbladder that normally form the common bile duct, which then runs from the liver to the duodenum.
- Not all bile runs directly into the duodenum. About fifty percent of the liver bile produced by the liver is first stored in the gallbladder, into a pear-shaped organ located directly below the liver.
- After then, when the food is eaten, the gallbladder contracts and releases stored live bile into the duodenum that helps to break down the fats.
Role of liver bile in fat digestion and absorption
Liver bile is the derivatives of cholesterol that are usually synthesized in the hepatocyte. Cholesterol that are ingested as the part of the diet or that derived from the hepatic synthesis that converted into the liver bile acids colic and chenodeoxycholic acids, that then conjugated into amino acid like glycine.
Pattern and control of liver bile secretion
The flow of liver bile is so much lowest during the fasting mood and a majority of liver bile is diverted into the gallbladder for the concentration. The liver bile is flow in higher amount during food intake. When chime from an ingested meal enters into the small intestine, partially digested protein and fats stimulate secretion of secretin and cholecystokinin. Both these are very much important for the liver bile flow.
Function of liver bile
The main function of liver bile includes the following:
- The major function of liver bile is, to drain waste material from the liver into duodenum.
- The liver bile in normally greenish-yellow colored fluid that consisting of bile salt, cholesterol and waste product that is secreted by the liver cells for breakdown of fats and vitamins during digestion.
What is hcc liver cancer
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver. In worldwide hepatocellular carcinoma is now the third leading cause of cancer death. Most effected person by heptocellular carcinoma in Asia and Africa.
The presentation of hepatocellular carcinoma has evolved significantly over the past few decades. While, in the past, hepatocellular carcinoma generally presented at an advanced stage with right upper quadrant pain, weight loss, and signs of decompensate liver disease, hepatocellular carcinoma is now increasingly recognized at a much earlier stage as a consequence of the routine screening of patients with known cirrhosis, using cross-sectional imaging studies and serum alpha-fetoprotein measurements.
Resection may benefit certain patients, albeit mostly transiently. Many patients are not candidates given the advanced stage of their cancer at diagnosis or their degree of liver disease and, ideally, could be cured by liver transplantation. Globally, only a fraction of all patients have access to transplantation, and, even in the developed world, organ shortage remains a major limiting factor. In these patients, local ablative therapies, including radiofrequency ablation, chemoembolization, and potentially novel chemotherapeutic agents, may extend life and provide palliation.
Causes of hcc liver cancer
Hepatocellular carcinoma accounts for most liver cancers. This type of cancer occurs more often in men than women. It is usually seen in people age 50 or older. However, the age varies in different parts of the world.
The disease is more common in parts of Africa and Asia than in North or South America and Europe.
Hepatocellular carcinoma is not the same as metastatic liver cancer, which starts in another organ (such as the breast or colon) and spreads to the liver.
In most cases, the cause of liver cancer is usually scarring of the liver (cirrhosis). Cirrhosis may be caused by:
- Alcohol abuse (the most common cause in the United States)
- Autoimmune diseases of the liver
- Hepatitis B or C virus infection
- Inflammation of the liver that is long-term (chronic)
- Iron overload in the body (hemochromatosis)
Patients with hepatitis B or C are at risk for liver cancer, even if they have not developed cirrhosis.
Symptoms of hcc liver cancer
- Abdominal pain or tenderness, especially in the upper-right part
- Easy bruising or bleeding
- Enlarged abdomen
- Yellow skin or eyes (jaundice)
Treatment of hcc liver cancer
Aggressive surgery or a liver transplant can successfully treat small or slow-growing tumors if they are diagnosed early. However, few patients are diagnosed early.
Chemotherapy delivered straight into the liver with a catheter can help, but it will not cure the disease. Radiation treatments in the area of the cancer may also be helpful. However, many patients have liver cirrhosis or other liver diseases that make these treatments more difficult.
Sorafenib tosylate (Nexavar), an oral medicine that blocks tumor growth, is now approved for patients with advanced hepatocellular carcinoma.